Antihypertensive effects of peroxisome proliferator-activated receptor-β/δ activation

M Toral, M Romero, F Perez-Vizcaino… - American Journal …, 2017 - journals.physiology.org
… atherosclerotic, anti-inflammatory and vasodilatory effects (47… /δ ligands, which produced a
strong inhibitory effect on aortic … include the upregulation of antioxidant genes, such as GPx1, …

Molecular mechanisms and therapeutic perspectives of peroxisome proliferatoractivated receptor α agonists in cardiovascular health and disease

Y Pu, CK Cheng, H Zhang, JY Luo… - Medicinal Research …, 2023 - Wiley Online Library
… the ligand-activated transcription factor of a nuclear receptor … cell-tube in streptozotocin-induced
diabetic mice are absent by … -remodeling, anti-inflammatory, and antioxidative effects on …

Targeting endothelial dysfunction and inflammation

L Wang, CK Cheng, M Yi, KO Lui, Y Huang - Journal of molecular and …, 2022 - Elsevier
… 4 inhibitors, peroxisome proliferator-activated receptor δ … vascular beneficial, anti-oxidative
and anti-inflammatory in either … RAS inhibitors, PPARδ ligands, GLP-1 elevators and GLP-1 …

[PDF][PDF] The role of PPARgamma in cardiovascular diseases

M Kvandová, M Majzúnová, I Dovinová - Physiol Res, 2016 - academia.edu
Peroxisome proliferator-activated receptors (PPAR) belong … In streptozotocininduced
diabetes in rats, bezafibrate and PIO … type 2 diabetic patients by the anti-inflammatory and …

PPAR-δ: A key nuclear receptor in vascular function and remodeling

L Xiao, N Wang - Journal of Molecular and Cellular Cardiology, 2022 - Elsevier
Peroxisome proliferator-activated receptors (PPARs) are … diabetic db/db mice [38],
streptozotocin-induced diabetic rats [39]… while enhanced the expression of anti-inflammatory

Partial Synthetic PPARƳ Derivative Ameliorates Aorta Injury in Experimental Diabetic Rats Mediated by Activation of miR-126-5p Pi3k/AKT/PDK 1/mTOR Expression

YM Ahmed, R Orfali, NS Abdelwahab, HM Hassan… - Pharmaceuticals, 2022 - mdpi.com
Peroxisome proliferator-activated receptor PPAR) agonists have … Streptozotocin-Induced
T2D through stimulating local … our results and confirmed the anti-inflammatory and anti-oxidant …

The cardiovascular protective effects of chrysin: a narrative review on experimental researches

T Farkhondeh, S Samarghandian… - … Agents in Medicinal …, 2019 - ingentaconnect.com
effect is due to its antioxidative effects and antiinflammatory … PDGF receptors and ligands
are markedly increased in … , and pancreas in streptozotocin-induced diabetic rats. Can. J. …

Impact of the renin–angiotensin system on the endothelium in vascular dementia: Unresolved issues and future perspectives

FY Noureddine, R Altara, F Fan… - International journal of …, 2020 - mdpi.com
… memory in a streptozotocin-induced diabetes rat model [24]. … proliferator-activated receptor
α (PPARα) and PPARγ [36,37]. … other hand, holds antioxidant and anti-inflammatory effects in …

[HTML][HTML] New insights into oxidative stress and inflammation during diabetes mellitus-accelerated atherosclerosis

T Yuan, T Yang, H Chen, D Fu, Y Hu, J Wang, Q Yuan… - Redox biology, 2019 - Elsevier
peroxisome proliferator activated receptor … also decreases anti-inflammatory protein A20
expression via O-… AdipoR2 binding also increasing the expression of PPARα ligands that …

Diabetic cardiomyopathy: molecular mechanisms, detrimental effects of conventional treatment, and beneficial effects of natural therapy

B Parim, VV Sathibabu Uddandrao, G Saravanan - Heart Failure Reviews, 2019 - Springer
… acids (FFA), peroxisome proliferator-activated receptor (PPAR)-… The function of every PPAR
subtype depends on ligand … , and antioxidant levels of aorta and mRNA expression of NOS, …